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So Laxative pills that contain Senna ingredients are the best natural constipation tablets. Laboratory studies have shown that the active ingredient of the Senna (Senozid) doesn’t absorb in the small intestine and is converted into the active metabolite of Rhein-Anthrone by the normal flora in the large intestine. Beecham's Pills were a laxative first marketed about 1842 in Wigan, Lancashire.

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